Molecular Cloning and Disease Association of Hepatitis G Virus: A Transfusion-Transmissible Agent
Jeff Linnen(Jisc), J. Wages(Jisc), Z Y Zhang-Keck(Jisc), Kirk E. Fry(Jisc), K. Krawczyński(Centers for Disease Control and Prevention), Harvey J. Alter(National Institutes of Health Clinical Center), Eugene V. Koonin(National Center for Biotechnology Information), Margaret Gallagher(Centers for Disease Control and Prevention), Miriam J. Alter(Centers for Disease Control and Prevention), Stephanos J. Hadziyannis(Hippocration General Hospital), Peter Karayiannis(St Thomas' Hospital), Kevin Fung(Jisc), Yoshiyuki Nakatsuji(National Institutes of Health Clinical Center), J. Wai‐Kuo Shih(National Institutes of Health Clinical Center), L M Young(Jisc), Michael Piatak(Jisc), Cameron Hoover(Jisc), John Fernandez(Jisc), Stacie Chen(Jisc), Jian-Chao Zou(Jisc), Timothy T. Morris(Centers for Disease Control and Prevention), Kenneth C. Hyams(Naval Medical Research Command), S. Ismay(Australian Red Cross Lifeblood), Jeffrey D. Lifson(Jisc), Georg Heß(Roche (United States)), Steven K. H. Foung(Jisc), Howard Thomas(St Thomas' Hospital), Daniel W. Bradley(Kelly Services (United States)), Harold S. Margolis(Centers for Disease Control and Prevention), Jungsuh P. Kim(Jisc)
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Abstract
An RNA virus, designated hepatitis G virus (HGV), was identified from the plasma of a patient with chronic hepatitis. Extension from an immunoreactive complementary DNA clone yielded the entire genome (9392 nucleotides) encoding a polyprotein of 2873 amino acids. The virus is closely related to GB virus C (GBV-C) and distantly related to hepatitis C virus, GBV-A, and GBV-B. HGV was associated with acute and chronic hepatitis. Persistent viremia was detected for up to 9 years in patients with hepatitis. The virus is transfusion-transmissible. It has a global distribution and is present within the volunteer blood donor population in the United States.
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