SV-IV, a major protein secreted from rat seminal vesicle epithelium, promotes lymphocyte cytotoxic activity against the lymphoblastoid Raji cell line in human peripheral blood mononuclear cells
Gianfranco Peluso(Institute of Protein Biochemistry), Magda Marchese(Institute of Genetics and Biophysics), Annita Furgi(Institute of Genetics and Biophysics), Marilena Ranieri(Institute of Genetics and Biophysics), Silvana Russo Spena(Institute of Genetics and Biophysics), Giampietro Ravagnan, Maria Pia Fuggetta, Raffaele Porta(University of Naples Federico II), Vittoria Metafora(Institute of Genetics and Biophysics), Salvatore Metafora(Institute of Genetics and Biophysics)
International Journal of Cancer
July 17, 1997
Cited by 6
Abstract
The treatment of human peripheral blood mononuclear cells (PBMC) with micromolar concentrations of SV-IV, a major protein secreted from the rat seminal vesicle epithelium, promotes in this cell population a marked cytotoxic activity against the Raji lymphoblastoid cell line. This activity is apparently due to cell-to-cell contact interactions. The expression of HLA DR on Raji cells has a modulatory effect on the SV-IV-induced cytotoxic activity. The experimental evidence strongly suggests that the cytotoxic effector cells are functionally activated NK cells.
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