Flexible Porous Metal-Organic Frameworks for a Controlled Drug Delivery

Patricia Horcajada(Université de Montpellier), Christian Serre(Institut Charles Gerhardt Montpellier), Guillaume Maurin(Centre National de la Recherche Scientifique), Naseem A. Ramsahye(Institut Charles Gerhardt Montpellier), Francisco Balas(Universidad Complutense de Madrid), María Vallet‐Regí(Institut Universitaire de France), Muriel Sebban(Institut Universitaire de France), Francis Taulelle(Institut Charles Gerhardt Montpellier), Gérard Férey(Institut Charles Gerhardt Montpellier)
Journal of the American Chemical Society
May 1, 2008
10.1021/ja710973k
Cited by 1,770

Abstract

Flexible nanoporous chromium or iron terephtalates (BDC) MIL-53(Cr, Fe) or M(OH)[BDC] have been used as matrices for the adsorption and in vitro drug delivery of Ibuprofen (or alpha- p-isobutylphenylpropionic acid). Both MIL-53(Cr) and MIL-53(Fe) solids adsorb around 20 wt % of Ibuprofen (Ibuprofen/dehydrated MIL-53 molar ratio = 0.22(1)), indicating that the amount of inserted drug does not depend on the metal (Cr, Fe) constitutive of the hybrid framework. Structural and spectroscopic characterizations are provided for the solid filled with Ibuprofen. In each case, the very slow and complete delivery of Ibuprofen was achieved under physiological conditions after 3 weeks with a predictable zero-order kinetics, which highlights the unique properties of flexible hybrid solids for adapting their pore opening to optimize the drug-matrix interactions.

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