Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profile

Haifeng Sun; Liyuan Zhu; Huicui Yang; Wangke Qian; Lin Guo; Shengbin Zhou; Bo Gao; Zeng Li; Yu Zhou; Hualiang Jiang; Kaixian Chen; Xuechu Zhen; Hong Liu

doi:10.1016/j.bmc.2012.12.016

Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profile

Haifeng Sun(Chinese Academy of Sciences), Liyuan Zhu(Shanghai Institute of Materia Medica), Huicui Yang(Soochow University), Wangke Qian(Chinese Academy of Sciences), Lin Guo(Shanghai Institute of Materia Medica), Shengbin Zhou(Chinese Academy of Sciences), Bo Gao(Soochow University), Zeng Li(Shanghai Institute of Materia Medica), Yu Zhou(Chinese Academy of Sciences), Hualiang Jiang(Chinese Academy of Sciences), Kaixian Chen(Chinese Academy of Sciences), Xuechu Zhen(Soochow University), Hong Liu(Shanghai Institute of Materia Medica)

Bioorganic & Medicinal Chemistry

December 21, 2012

10.1016/j.bmc.2012.12.016

Cited by 73Open Access

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