Alteration of Plasma Membrane Organization by an Anticancer Lysophosphatidylcholine Analogue Induces Intracellular Acidification and Internalization of Plasma Membrane Transporters in Yeast

Abstract

The anti-tumor lipid edelfosine alters lipid raft integrity. How this signals inhibition of growth is not understood. Results: Disruption of plasma membrane domain organization triggers the selective removal of lipid raft-associated transporters altering pH homeostasis. Conclusion: Raft integrity controls pH homeostasis and growth. Significance: Choline-containing lysolipid analogues induce biophysical modifications of microdomains leading to inhibition of cell growth through alteration of pH homeostasis.