The natural history of HIV infection in intravenous drug users

Giovanni Rezza(Ministero della Salute), Adriano Lazzarin(University of Milan), Gioacchino Angarano(University of Milan), Alessandro Sinicco(University of Milan), R. Pristerà(Ospedale di Bolzano), L Ortona(University of Milan), M Barbanera(Ospedale di Bolzano), Sergio Gafà(Ospedale di Bolzano), Umberto Tirelli(Centro di Riferimento Oncologico), B Salassa(Ospedale di Bolzano), Ennio Ricchi(University of Milan), F Aiuti(Ministero della Salute), Francesca Menniti‐Ippolito(Ospedale di Bolzano)
AIDS
February 1, 1989
10.1097/00002030-198902000-00006
Cited by 59

Abstract

A multicentre cohort study was carried out to estimate the incidence of AIDS and HIV-related conditions in newly infected intravenous drug users (IVDU). The enrollment criteria included the identification of the seroconversion time. Two hundred and five subjects entered the study, and were followed for a mean of 26 months. Twelve subjects developed clinical AIDS over a 4-year period. The actuarial incidence of AIDS estimated by Kaplan-Meier survival technique was 17.8% by 4 years since seroconversion. The risk of developing AIDS increased significantly after 24 months from seroconversion. Relatively small figures accounted for the lack of statistical association between the risk factors investigated and the disease status.

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