Alcoholic Liver Disease: A Synopsis of the Charles Lieber's Memorial Symposia 2009-2012

Manuela G. Neuman(University of Toronto), Lawrence Cohen(Health Sciences Centre), S. Zakhari(National Institutes of Health), Radu M. Nanau(University of Toronto), Sebastian Mueller(Heidelberg University), Marguerite Schneider(Stellenbosch University), Charles Parry(South African Medical Research Council), Rachele Isip(University of Toronto), Helmut K. Seitz(Heidelberg University)
Alcohol and Alcoholism
May 9, 2014
10.1093/alcalc/agu021
Cited by 10Open Access
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Abstract

This paper is based upon the 'Charles Lieber Satellite Symposia' organized by Manuela G. Neuman at each of the 2009-2012 Research Society on Alcoholism (RSA) Annual Meetings. The presentations represent a broad spectrum dealing with alcoholic liver disease (ALD). In addition, a literature search (2008-2013) in the discussed area was performed in order to obtain updated data. The presentations are focused on genetic polymorphisms of ethanol metabolizing enzymes and the role of cytochrome P4502E1 (CYP2E1) in ALD. In addition, alcohol-mediated hepatocarcinogenesis, immune response to alcohol and fibrogenesis in alcoholic hepatitis as well as its co-morbidities with chronic viral hepatitis infections in the presence or absence of human deficiency virus are discussed. Finally, emphasis was led on alcohol and drug interactions as well as liver transplantation for end-stage ALD.

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