Abscisic Acid Inhibits Type 2C Protein Phosphatases via the PYR/PYL Family of START Proteins

Sang‐Youl Park(University of California, Riverside), Pauline Fung(University of Toronto), Noriyuki Nishimura(University of California San Diego), Davin R. Jensen(Medical College of Wisconsin), Hiroaki Fujii(University of California, Riverside), Yang Zhao(University of Toronto), Shelley Lumba(University of Toronto), Julia Santiago(Instituto de Biología Molecular y Celular de Plantas), Américo Rodrigues(Instituto de Biología Molecular y Celular de Plantas), Tsz-fung F. Chow(University of Toronto), Simon E. Alfred(University of Toronto), Dario Bonetta(Ontario Tech University), Ruth Finkelstein(University of California, Santa Barbara), Nicholas J. Provart(University of Toronto), Darrell Desveaux(University of Toronto), Pedro L. Rodrı́guez(Instituto de Biología Molecular y Celular de Plantas), Peter McCourt(University of Toronto), Jian‐Kang Zhu(University of California, Riverside), Julian I. Schroeder(University of California San Diego), Brian F. Volkman(Medical College of Wisconsin), Sean R. Cutler(University of California, Riverside)
Science
April 30, 2009
10.1126/science.1173041
Cited by 2,995Open Access
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Abstract

ABA Receptor Rumbled? The plant hormone abscisic acid (ABA) is critical for normal development and for mediating plant responses to stressful environmental conditions. Now, two papers present analyses of candidate ABA receptors (see the news story by Pennisi ). Ma et al. (p. 1064; published online 30 April) and Park et al. (p. 1068, published online 30 April) used independent strategies to search for proteins that physically interact with ABI family phosphatase components of the ABA response signaling pathway. Both groups identified different members of the same family of proteins, which appear to interact with ABI proteins to form a heterocomplex that can act as the ABA receptor. The variety of both families suggests that the ABA receptor may not be one entity, but rather a class of closely related complexes, which may explain previous difficulties in establishing its identity.

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