A Biocompatible Method of Decorporation: Bisphosphonate-Modified Magnetite Nanoparticles to Remove Uranyl Ions from Blood
Ling Wang(Hong Kong University of Science and Technology), Zhimou Yang(Hong Kong University of Science and Technology), Jinhao Gao(University of Hong Kong), Keming Xu(Hong Kong University of Science and Technology), Hongwei Gu(Hong Kong University of Science and Technology), Bei Zhang(Hong Kong University of Science and Technology), Xixiang Zhang(University of Hong Kong), Bing Xu(University of Hong Kong)
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Abstract
We report on the use of bisphosphonate to functionalize Fe3O4 magnetic nanoparticles via dopamine (DA) linkage. Using tetraethyl-3-aminopropane-1,1-bisphosphonate (BP) as the functional molecule, we created a system with an Fe3O4-DA-BP nanostructure, which possesses high specificity for removing uranyl ions from water or blood. This work demonstrates that magnetic nanoparticles, combined with specific receptor-ligand interactions, promise a sensitive and rapid platform for the detection, recovery, and decorporation of metal toxins from biological environment.
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