Cloning of the γ Chain of the Human IL-2 Receptor
Toshikazu Takeshita(Tohoku University), Hironobu Asao(Tohoku University), Kiyoshi Ohtani(Tohoku University), Naoto Ishii(Tohoku University), Satoru Kumaki(Tohoku University), Nobuyuki Tanaka(Tohoku University), Hiroshi Munakata(Tohoku University), Masataka Nakamura(Tohoku University), Kazuo Sugamura(Tohoku University)
Cited by 843
Abstract
A third subunit, the gamma chain, of the human interleukin-2 receptor (IL-2R) was identified, and a complementary DNA clone encoding this member of the cytokine receptor family was isolated. The gamma chain is necessary for the formation of the high- and intermediate-affinity receptors, which consists of alpha beta gamma heterotrimers and beta gamma heterodimers, respectively. The IL-2R on murine fibroblastoid cells can be internalized after binding IL-2 only if the gamma chain is present; alpha and beta are insufficient for internalization. Thus, the gamma chain is an indispensable component of the functional IL-2R.
Related Papers
No related papers found
Powered by citation graph analysis