Structure and mechanism of action of the hydroxy–aryl–aldehyde class of IRE1 endoribonuclease inhibitors

Mário Sanches(Mount Sinai Hospital), Nicole M. Duffy(Mount Sinai Hospital), Manisha Talukdar(Lunenfeld-Tanenbaum Research Institute), N. Thevakumaran(Lunenfeld-Tanenbaum Research Institute), David Chiovitti(Lunenfeld-Tanenbaum Research Institute), Marella D. Canny(Lunenfeld-Tanenbaum Research Institute), Kenneth Lee(Lunenfeld-Tanenbaum Research Institute), Igor Kurinov(Argonne National Laboratory), David Uehling(Ontario Institute for Cancer Research), Rima Al‐awar(Ontario Institute for Cancer Research), Gennadiy Poda(Ontario Institute for Cancer Research), Michaël Prakesch(Ontario Institute for Cancer Research), Brian J. Wilson(Ontario Institute for Cancer Research), Victor Tam(MannKind Corporation (United States)), Colleen Schweitzer(MannKind Corporation (United States)), András Toró(MannKind Corporation (United States)), Julie L. Lucas(MannKind Corporation (United States)), D Vuga(MannKind Corporation (United States)), Lynn Lehmann, Daniel Durocher(University of Toronto), Qingping Zeng(MannKind Corporation (United States)), John B. Patterson(MannKind Corporation (United States)), Frank Sicheri(University of Toronto)
Nature Communications
August 28, 2014
10.1038/ncomms5202
Cited by 131Open Access
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