The Biologic Clock: The Mitochondria?
Denham Harman(University of Nebraska at Omaha)
Cited by 1,975
Abstract
ABSTRACT: The author suggests that the maximal life span of a given mammalian species is largely an expression of genetic control over the rate of oxygen utilization. The latter determines the rate of accumulation of mitochondrial damage produced by free radical reactions, the rate increasing with the rate of oxygen consumption, which ultimately causes death.
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