The Biologic Clock: The Mitochondria?

Denham Harman(University of Nebraska at Omaha)
Journal of the American Geriatrics Society
April 1, 1972
Cited by 1,975

Abstract

ABSTRACT: The author suggests that the maximal life span of a given mammalian species is largely an expression of genetic control over the rate of oxygen utilization. The latter determines the rate of accumulation of mitochondrial damage produced by free radical reactions, the rate increasing with the rate of oxygen consumption, which ultimately causes death.


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