A New DNA Marker Tightly Linked to the Fragile X Locus ( <i>FRAXA</i> )
G K Suthers(Women's and Children's Hospital), David F. Callen(Women's and Children's Hospital), V.J. Hyland(Women's and Children's Hospital), H.M. Kozman(Women's and Children's Hospital), Elizabeth Baker(Women's and Children's Hospital), Helen J. Eyre(Women's and Children's Hospital), P S Harper(University Hospital of Wales), S. H. Roberts(University Hospital of Wales), M. C. Hors‐Cayla(Hôpital des Enfants), K E Davies(University of Oxford), M.V. Bell(University of Oxford), G.R. Sutherland(Women's and Children's Hospital)
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Abstract
The fragile X syndrome is the most common cause of familial mental retardation. Genetic counseling and gene isolation are hampered by a lack of DNA markers close to the disease locus. Two somatic cell hybrids that each contain a human X chromosome with a breakpoint close to the fragile X locus have been characterized. A new DNA marker (DXS296) lies between the chromosome breakpoints and is the closest marker to the fragile X locus yet reported. The Hunter syndrome gene, which causes iduronate sulfatase deficiency, is located at the X chromosome breakpoint that is distal to this new marker, thus localizing the Hunter gene distal to the fragile X locus.
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