Preparation and Evaluation of Unimolecular Pentavalent and Hexavalent Antigenic Constructs Targeting Prostate and Breast Cancer: A Synthetic Route to Anticancer Vaccine Candidates
Govind Ragupathi(Columbia University), Fusataka Koide(Columbia University), Philip O. Livingston(Kettering University), Young Shin Cho(Kettering University), Atsushi Endo(Columbia University), Qian Wan(Kettering University), Maria Spassova(Kettering University), Stacy J. Keding(Columbia University), Jennifer R. Allen(Kettering University), Ouathek Ouerfelli(Kettering University), Rebecca M. Wilson(Columbia University), Samuel J. Danishefsky(Kettering University)
Cited by 150
Abstract
Several novel, fully synthetic, carbohydrate-based antitumor vaccines have been assembled. Each construct consists of multiple cancer-related antigens displayed on a single polypeptide backbone. Recent advances in synthetic methodology have allowed for the incorporation of a complex oligosaccharide terminating in a sialic acid residue (i.e., GM2) as one of the carbohydrate antigens. Details of the vaccine synthesis as well as the results of preliminary immunological investigations are described herein.
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