Detectable clonal mosaicism and its relationship to aging and cancer

Kevin B. Jacobs; Meredith Yeager; Weiyin Zhou; Sholom Wacholder; Zhaoming Wang; Benjamín Rodríguez‐Santiago; Amy Hutchinson; Xiang Deng; Chenwei Liu; Marie-Josèphe Horner; Michael Cullen; Caroline G. Epstein; Laurie Burdett; Michael Dean; Nilanjan Chatterjee; Joshua N. Sampson; Charles C. Chung; Joseph Kovaks; Susan M. Gapstur; Victoria L. Stevens; Lauren T. Teras; Mia M. Gaudet; Demetrius Albanes; Stephanie J. Weinstein; Jarmo Virtamo; Philip R. Taylor; Neal D. Freedman; Christian C. Abnet; Alisa M. Goldstein; Nan Hu; Kai Yu; Jian‐Min Yuan; Linda M. Liao; Ti Ding; You‐Lin Qiao; Yu-Tang Gao; Woon‐Puay Koh; Yong-Bing Xiang; Ze-Zhong Tang; Jin‐Hu Fan; Melinda C. Aldrich; Christopher I. Amos; William J. Blot; Cathryn H. Bock; Elizabeth M. Gillanders; Curtis C. Harris; Christopher A. Haiman; Brian E. Henderson; Laurence N. Kolonel; Loı̈c Le Marchand; Lorna H. McNeill; Benjamin A. Rybicki; Ann G. Schwartz; Lisa B. Signorello; Margaret R. Spitz; John K. Wiencke; Margaret Wrensch; Xifeng Wu; Krista A. Zanetti; Regina G. Ziegler; Jonine D. Figueroa; Montserrat García‐Closas; Núria Malats; Gaëlle Marenne; Ludmila Prokunina‐Olsson; Dalsu Baris; Molly Schwenn; Alison Johnson; Maria Teresa Landi; Lynn R. Goldin; Dario Consonni; Pier Alberto Bertazzi; Melissa Rotunno; Preetha Rajaraman; Ulrika Andersson; Laura E. Beane Freeman; Christine D. Berg; Julie E. Buring; Mary Ann Butler; Tania Carreón; Maria Feychting; Anders Ahlbom; J. Michael Gaziano; Graham G. Giles; Göran Hallmans; Susan E. Hankinson; Patricia Hartge; Roger Henriksson; Peter D. Inskip; Christoffer Johansen; Annelie Landgren; Roberta McKean‐Cowdin; Dominique S. Michaud; Beatrice S. Melin; Ulrike Peters; Avima M. Ruder; Howard D. Sesso; Gianluca Severi; Xiao‐Ou Shu; Kala Visvanathan; Emily White; Alicja Wolk; Anne Zeleniuch‐Jacquotte; Wei Zheng; Debra T. Silverman; Manolis Kogevinas; Juan R. González; Olaya Villa; Donghui Li; Eric J. Duell; Harvey A. Risch; Sara H. Olson; Charles Kooperberg; Brian M. Wolpin; Li Jiao; Manal M. Hassan; William Wheeler; Alan A. Arslan; H. Bas Bueno‐de‐Mesquita; Charles S. Fuchs; Steven Gallinger; Myron D. Gross; Elizabeth A. Holly; Alison P. Klein; Andrea Z. LaCroix; Margaret T. Mandelson; Gloria M. Petersen; Marie‐Christine Boutron‐Ruault; Paige M. Bracci; Federico Canzian; Kenneth Chang; Michelle Cotterchio; Edward L. Giovannucci; Michael Goggins; Judith A. Hoffman Bolton; Mazda Jenab; Kay‐Tee Khaw; Vittorio Krogh; Robert C. Kurtz; Robert R. McWilliams; Julie B. Mendelsohn; Kari G. Rabe; Elio Ríboli; Anne Tjønneland; Geoffrey S. Tobias; Dimitrios Trichopoulos; Joanne W. Elena; Herbert Yu; Laufey T. Ámundadóttir; Rachael Z. Stolzenberg‐Solomon; Peter Kraft; Fredrick R. Schumacher; Daniel O. Stram; Sharon A. Savage; Lisa Mirabello; Irene L. Andrulis; Jay S. Wunder; Ana Patiño‐García; Luis Sierrasesúmaga; Donald A. Barkauskas; Richard Görlick; Mark P. Purdue; Wong‐Ho Chow; Lee E. Moore; Kendra Schwartz; Faith G. Davis; Ann W. Hsing; Sonja I. Berndt; Amanda Black; Nicolas Wentzensen; Louise A. Brinton; Jolanta Lissowska; Beata Pepłońska; Katherine A. McGlynn; Michael B. Cook; Barry I. Graubard; Christian P. Kratz; Mark H. Greene; Ralph L. Erickson; David J. Hunter; Gilles Thomas; Robert N. Hoover; Francisco X. Real; Joseph F. Fraumeni; Neil E. Caporaso; Margaret A. Tucker; Nathaniel Rothman; Luis A. Pérez‐Jurado; Stephen J. Chanock

doi:10.1038/ng.2270

Detectable clonal mosaicism and its relationship to aging and cancer

Kevin B. Jacobs(National Cancer Institute), Meredith Yeager(National Cancer Institute), Weiyin Zhou(National Cancer Institute), Sholom Wacholder(National Cancer Institute), Zhaoming Wang(National Cancer Institute), Benjamín Rodríguez‐Santiago(Universitat Pompeu Fabra), Amy Hutchinson(National Cancer Institute), Xiang Deng(National Cancer Institute), Chenwei Liu(National Cancer Institute), Marie-Josèphe Horner(National Cancer Institute), Michael Cullen(National Cancer Institute), Caroline G. Epstein(National Cancer Institute), Laurie Burdett(National Cancer Institute), Michael Dean(Center for Cancer Research), Nilanjan Chatterjee(National Cancer Institute), Joshua N. Sampson(National Cancer Institute), Charles C. Chung(National Cancer Institute), Joseph Kovaks(National Cancer Institute), Susan M. Gapstur(American Cancer Society), Victoria L. Stevens(American Cancer Society), Lauren T. Teras(American Cancer Society), Mia M. Gaudet(American Cancer Society), Demetrius Albanes(National Cancer Institute), Stephanie J. Weinstein(National Cancer Institute), Jarmo Virtamo(Finnish Institute for Health and Welfare), Philip R. Taylor(National Cancer Institute), Neal D. Freedman(National Cancer Institute), Christian C. Abnet(National Cancer Institute), Alisa M. Goldstein(National Cancer Institute), Nan Hu(National Cancer Institute), Kai Yu(National Cancer Institute), Jian‐Min Yuan(University of Minnesota), Linda M. Liao(National Cancer Institute), Ti Ding(Shanxi Provincial Cancer Hospital), You‐Lin Qiao(Chinese Academy of Medical Sciences & Peking Union Medical College), Yu-Tang Gao(Shanghai Cancer Institute), Woon‐Puay Koh(National University of Singapore), Yong-Bing Xiang(Shanghai Cancer Institute), Ze-Zhong Tang(Shanxi Provincial Cancer Hospital), Jin‐Hu Fan(Chinese Academy of Medical Sciences & Peking Union Medical College), Melinda C. Aldrich(Vanderbilt University), Christopher I. Amos(The University of Texas MD Anderson Cancer Center), William J. Blot(Vanderbilt University Medical Center), Cathryn H. Bock(Wayne State University), Elizabeth M. Gillanders, Curtis C. Harris(Center for Cancer Research), Christopher A. Haiman(University of Southern California), Brian E. Henderson(University of Southern California), Laurence N. Kolonel(University of Hawaiʻi at Mānoa), Loı̈c Le Marchand(University of Hawaiʻi at Mānoa), Lorna H. McNeill(The University of Texas MD Anderson Cancer Center), Benjamin A. Rybicki(Henry Ford Hospital), Ann G. Schwartz(Wayne State University), Lisa B. Signorello(Vanderbilt University Medical Center), Margaret R. Spitz(Baylor College of Medicine), John K. Wiencke(University of California, San Francisco), Margaret Wrensch(University of California, San Francisco), Xifeng Wu(The University of Texas MD Anderson Cancer Center), Krista A. Zanetti, Regina G. Ziegler(National Cancer Institute), Jonine D. Figueroa(National Cancer Institute), Montserrat García‐Closas(National Cancer Institute), Núria Malats(Spanish National Cancer Research Centre), Gaëlle Marenne(Spanish National Cancer Research Centre), Ludmila Prokunina‐Olsson(National Cancer Institute), Dalsu Baris(National Cancer Institute), Molly Schwenn, Alison Johnson(Vermont Cancer Support Network), Maria Teresa Landi(National Cancer Institute), Lynn R. Goldin(National Cancer Institute), Dario Consonni(University of Milan), Pier Alberto Bertazzi(University of Milan), Melissa Rotunno(National Cancer Institute), Preetha Rajaraman(National Cancer Institute), Ulrika Andersson(Umeå University), Laura E. Beane Freeman(National Cancer Institute), Christine D. Berg(Center for Cancer Research), Julie E. Buring(Harvard University), Mary Ann Butler(Centers for Disease Control and Prevention), Tania Carreón(Centers for Disease Control and Prevention), Maria Feychting(Karolinska Institutet), Anders Ahlbom(Karolinska Institutet), J. Michael Gaziano(Brigham and Women's Hospital), Graham G. Giles(Cancer Council Victoria), Göran Hallmans(Umeå University), Susan E. Hankinson(Brigham and Women's Hospital), Patricia Hartge(National Cancer Institute), Roger Henriksson(Umeå University), Peter D. Inskip(National Cancer Institute), Christoffer Johansen(Danish Cancer Society), Annelie Landgren(National Cancer Institute), Roberta McKean‐Cowdin(University of Southern California), Dominique S. Michaud(Imperial College London), Beatrice S. Melin(Umeå University), Ulrike Peters(Fred Hutch Cancer Center), Avima M. Ruder(Centers for Disease Control and Prevention), Howard D. Sesso(Brigham and Women's Hospital), Gianluca Severi(Cancer Council Victoria), Xiao‐Ou Shu(Vanderbilt University Medical Center), Kala Visvanathan(Johns Hopkins University), Emily White(Fred Hutch Cancer Center), Alicja Wolk(Karolinska Institutet), Anne Zeleniuch‐Jacquotte(New York University), Wei Zheng(Vanderbilt University Medical Center), Debra T. Silverman(National Cancer Institute), Manolis Kogevinas(National School of Public Health), Juan R. González(Center for Research in Environmental Epidemiology), Olaya Villa, Donghui Li(The University of Texas MD Anderson Cancer Center), Eric J. Duell(Institut d'Investigació Biomédica de Bellvitge), Harvey A. Risch(Yale University), Sara H. Olson(Memorial Sloan Kettering Cancer Center), Charles Kooperberg(Fred Hutch Cancer Center), Brian M. Wolpin(Brigham and Women's Hospital), Li Jiao(Baylor College of Medicine), Manal M. Hassan(The University of Texas MD Anderson Cancer Center), William Wheeler(Information Management Services), Alan A. Arslan(New York University), H. Bas Bueno‐de‐Mesquita(University Medical Center Utrecht), Charles S. Fuchs(Brigham and Women's Hospital), Steven Gallinger(Lunenfeld-Tanenbaum Research Institute), Myron D. Gross(University of Minnesota), Elizabeth A. Holly(University of California, San Francisco), Alison P. Klein(Johns Hopkins University), Andrea Z. LaCroix(Fred Hutch Cancer Center), Margaret T. Mandelson(Fred Hutch Cancer Center), Gloria M. Petersen(Mayo Clinic in Florida), Marie‐Christine Boutron‐Ruault(Université Paris-Sud), Paige M. Bracci(University of California, San Francisco), Federico Canzian(German Cancer Research Center), Kenneth Chang(University of California, Irvine Medical Center), Michelle Cotterchio(University of Toronto), Edward L. Giovannucci(Brigham and Women's Hospital), Michael Goggins(Johns Hopkins University), Judith A. Hoffman Bolton(Johns Hopkins University), Mazda Jenab(Centre international de recherche sur le cancer), Kay‐Tee Khaw(University of Cambridge), Vittorio Krogh(Fondazione IRCCS Istituto Nazionale dei Tumori), Robert C. Kurtz(Memorial Sloan Kettering Cancer Center), Robert R. McWilliams(Mayo Clinic), Julie B. Mendelsohn(National Cancer Institute), Kari G. Rabe(Mayo Clinic in Florida), Elio Ríboli(Imperial College London), Anne Tjønneland(Danish Cancer Society), Geoffrey S. Tobias(National Cancer Institute), Dimitrios Trichopoulos(Harvard University), Joanne W. Elena(Center for Cancer Research), Herbert Yu(Yale University), Laufey T. Ámundadóttir(National Cancer Institute), Rachael Z. Stolzenberg‐Solomon(National Cancer Institute), Peter Kraft(Brigham and Women's Hospital), Fredrick R. Schumacher(University of Southern California), Daniel O. Stram(University of Southern California), Sharon A. Savage(National Cancer Institute), Lisa Mirabello(National Cancer Institute), Irene L. Andrulis(Lunenfeld-Tanenbaum Research Institute), Jay S. Wunder(Lunenfeld-Tanenbaum Research Institute), Ana Patiño‐García(Clinica Universidad de Navarra), Luis Sierrasesúmaga(Clinica Universidad de Navarra), Donald A. Barkauskas(University of Southern California), Richard Görlick(Albert Einstein College of Medicine), Mark P. Purdue(National Cancer Institute), Wong‐Ho Chow(National Cancer Institute), Lee E. Moore(National Cancer Institute), Kendra Schwartz(Wayne State University), Faith G. Davis(University of Illinois Chicago), Ann W. Hsing(National Cancer Institute), Sonja I. Berndt(National Cancer Institute), Amanda Black(National Cancer Institute), Nicolas Wentzensen(National Cancer Institute), Louise A. Brinton(National Cancer Institute), Jolanta Lissowska(The Maria Sklodowska-Curie National Research Institute of Oncology), Beata Pepłońska(Nofer Institute of Occupational Medicine), Katherine A. McGlynn(National Cancer Institute), Michael B. Cook(National Cancer Institute), Barry I. Graubard(National Cancer Institute), Christian P. Kratz(Medizinische Hochschule Hannover), Mark H. Greene(National Cancer Institute), Ralph L. Erickson(Walter Reed Army Institute of Research), David J. Hunter(Brigham and Women's Hospital), Gilles Thomas(Université Claude Bernard Lyon 1), Robert N. Hoover(National Cancer Institute), Francisco X. Real, Joseph F. Fraumeni(National Cancer Institute), Neil E. Caporaso(National Cancer Institute), Margaret A. Tucker(National Cancer Institute), Nathaniel Rothman(National Cancer Institute), Luis A. Pérez‐Jurado(Centre for Biomedical Network Research on Rare Diseases), Stephen J. Chanock(National Cancer Institute)

Nature Genetics

May 6, 2012

10.1038/ng.2270

Cited by 592Open Access

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