WTX is rarely mutated in acute myeloid leukemia
Carolyn Owen(Queen Mary University of London), Priya Virappane(Queen Mary University of London), Mary Alikian(Queen Mary University of London), Irina Stasevich(Queen Mary University of London), Karin E. Summers(Queen Mary University of London), Debra M. Lillington(Queen Mary University of London), Dominique Bonnet(Cancer Research UK), Alan K. Burnett(Cardiff University), Ken Mills(Queen's University Belfast), Tim Lister(Queen Mary University of London), Jude Fitzgibbon(Queen Mary University of London)
Cited by 10Open Access
Abstract
WTX (Wilms’ tumor gene on the X chromosome) is inactivated in 30% of Wilms’ tumors, mostly by chromosomal deletion.[1][1] The WTX protein is a component of the β-catenin destruction complex and promotes its ubiquitination and degradation, functioning as a negative regulator of WNT/β-catenin
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