Embryonic Stem Cell-Derived Glial Precursors: A Source of Myelinating Transplants
Oliver Brüstle(University of Bonn), Kimberly N. Jones(University of Bonn), Randall D. Learish(University of Wisconsin–Madison), Khalad Karram(University of Bonn), Khalid Choudhary(University of Bonn), Otmar D. Wiestler(University of Bonn), Ian D. Duncan(University of Wisconsin–Madison), Ronald D.G. McKay(National Institute of Neurological Disorders and Stroke)
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Abstract
Self-renewing, totipotent embryonic stem (ES) cells may provide a virtually unlimited donor source for transplantation. A protocol that permits the in vitro generation of precursors for oligodendrocytes and astrocytes from ES cells was devised. Transplantation in a rat model of a human myelin disease shows that these ES cell-derived precursors interact with host neurons and efficiently myelinate axons in brain and spinal cord. Thus, ES cells can serve as a valuable source of cell type-specific somatic precursors for neural transplantation.
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