Pharmacogenomics Knowledge for Personalized Medicine
Michelle Whirl‐Carrillo(Palo Alto University), Ellen M. McDonagh(Stanford University), Joan M. Hebert(Palo Alto University), Li Gong(Palo Alto University), Katrin Sangkuhl(Stanford University), Caroline F. Thorn(Stanford University), Russ B. Altman(Stanford University), Teri E. Klein(Palo Alto University)
Cited by 1,843
Abstract
The Pharmacogenomics Knowledgebase (PharmGKB) is a resource that collects, curates, and disseminates information about the impact of human genetic variation on drug responses. It provides clinically relevant information, including dosing guidelines, annotated drug labels, and potentially actionable gene-drug associations and genotype-phenotype relationships. Curators assign levels of evidence to variant-drug associations using well-defined criteria based on careful literature review. Thus, PharmGKB is a useful source of high-quality information supporting personalized medicine-implementation projects.
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