TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system

Guido Rindi(University of Parma), G. Klöppel(Christian-Albrechts-Universität zu Kiel), H. Alhman(University of Gothenburg), Martyn Caplin(The Royal Free Hospital), Anne Couvelard(Hôpital Beaujon), Wouter W. de Herder(Erasmus University Rotterdam), B. Erikssson(Uppsala University Hospital), Alberto Falchetti(University of Florence), Massimo Falconi(University of Verona), Paul Komminoth(Kantonsspital Baden), Meike Körner(University of Bern), José Manuel Lopes(Universidade do Porto), A. M. McNicol(Glasgow Royal Infirmary), Ola Nilsson(University of Gothenburg), Aurel Perren(University Hospital of Zurich), Aldo Scarpa(University of Verona), J-Y. Scoazec(Université Claude Bernard Lyon 1), Bertram Wiedenmann(Vivantes Klinikum), and all other Frascati Consensus Conference participants
Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
September 11, 2006
10.1007/s00428-006-0250-1
Cited by 1,572Open Access
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Abstract

The need for standards in the management of patients with endocrine tumors of the digestive system prompted the European Neuroendocrine Tumor Society (ENETS) to organize a first Consensus Conference, which was held in Frascati (Rome) and was based on the recently published ENETS guidelines on the diagnosis and treatment of digestive neuroendocrine tumors (NET). Here, we report the tumor-node-metastasis proposal for foregut NETs of the stomach, duodenum, and pancreas that was designed, discussed, and consensually approved at this conference. In addition, we report the proposal for a working formulation for the grading of digestive NETs based on mitotic count and Ki-67 index. This proposal, which needs to be validated, is meant to help clinicians in the stratification, treatment, and follow-up of patients.

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