High frequency of t(11;18) in gastric mucosa‐associated lymphoid tissue lymphomas in Taiwan, including one patient with high‐grade transformation

Shih‐Sung Chuang(Chi Mei Medical Center), Chuan Lee(Chi Mei Medical Center), Rifat Hamoudi(University College London), Hongxiang Liu(University College London), Po‐Shing Lee(Chi Mei Medical Center), Hongtao Ye(University College London), Tim C. Diss(University College London), Ahmet Doǧan(University College London), Peter G. Isaacson(University College London), Ming‐Qing Du(University College London)
British Journal of Haematology
December 20, 2002
10.1046/j.1365-2141.2003.04035.x
Cited by 51Open Access
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Abstract

t(11;18)(q21;q21), the most frequent chromosomal aberration of mucosa-associated lymphoid tissue (MALT) lymphoma, occurs in 30% of gastric patients. Although the translocation is often associated with an 'aggressive' course, it has not been described in transformed MALT lymphomas. We screened 15 gastric MALT lymphomas [three with concurrent or subsequent high-grade transformation and 11 diffuse large B-cell lymphomas (DLBCLs)] in Chinese patients for t(11;18). t(11;18) was found in 9/15 (60%) MALT lymphomas, but not in any DLBCLs. One patient, with subsequent high-grade transformation, showed the translocation in low- and high-grade lesions. t(11;18) was frequent in Chinese gastric MALT lymphomas and unusually one transformed lymphoma carried the translocation.

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