Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2S)-4-(2,5-Difluorophenyl)-N-[(3R,4S)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-N-methyl-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer

Christopher D. Cox(United States Military Academy), George D. Hartman(United States Military Academy), Thomayant Prueksaritanont(United States Military Academy), Paul J. Coleman(Merck & Co., Inc., Rahway, NJ, USA (United States)), Robert B. Lobell(United States Military Academy), Marc Abrams(Thomas Jefferson University), Nancy E. Kohl(United States Military Academy), Carmen Fernández‐Metzler(United States Military Academy), Kelly Hamilton(United States Military Academy), Eileen S. Walsh(United States Military Academy), R. M. Garbaccio(Merck & Co., Inc., Rahway, NJ, USA (United States)), Elizabeth Mahan(United States Military Academy), Vicki J. South(United States Military Academy), David B. Whitman(United States Military Academy), Ronald E. Diehl(United States Military Academy), Carolyn A. Buser(United States Military Academy), Chunze Li(United States Military Academy), Joseph P. Davide(United States Military Academy), Michael J. Breslin(United States Military Academy), Maricel Torrent(United States Military Academy), Youwei Yan(United States Military Academy), Lawrence C. Kuo(United States Military Academy), Donald E. Slaughter(United States Military Academy), Michael D. Schaber(United States Military Academy), Mark E. Fraley(United States Military Academy), Weikang Tao(Jiangsu Hengrui Medicine (China)), Hans E. Huber(United States Military Academy)

Journal of Medicinal Chemistry

June 25, 2008

Cited by 156

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Kinesin Spindle Protein (KSP) Inhibitors. 9. Discovery of (2<i>S</i>)-4-(2,5-Difluorophenyl)-<i>N</i>-[(3<i>R</i>,4<i>S</i>)-3-fluoro-1-methylpiperidin-4-yl]-2-(hydroxymethyl)-<i>N</i>-methyl-2-phenyl-2,5-dihydro-1<i>H</i>-pyrrole-1-carboxamide (MK-0731) for the Treatment of Taxane-Refractory Cancer