Virus interference. I. The interferon
Alick Isaacs(The Francis Crick Institute), J. Lindenmann(The Francis Crick Institute)
Proceedings of the Royal Society of London. Series B, Biological sciences
September 12, 1957
Cited by 3,403
Abstract
Abstract During a study of the interference produced by heat-inactivated influenza virus with the growth of live virus in fragments of chick chorio-allantoic membrane it was found that following incubation of heated virus with membrane a new factor was released. This factor, recognized by its ability to induce interference in fresh pieces of chorio-allantoic membrane, was called interferon. Following a lag phase interferon was first detected in the membranes after 3 h incubation and thereafter it was released into the surrounding fluid.
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