Homology of Cytokine Synthesis Inhibitory Factor (IL-10) to the Epstein-Barr Virus Gene BCRFI
Kevin W. Moore(Palo Alto Research Center), Paulo Vieira(Palo Alto Research Center), David Fiorentino(Palo Alto Research Center), Mary Trounstine(Palo Alto Research Center), Tariq A. Khan(Palo Alto Research Center), Timothy R. Mosmann(Palo Alto Research Center)
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Abstract
Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by T H 1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.
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