Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis

Xianbo Zuo(Anhui Medical University), Liangdan Sun(Anhui Medical University), Xianyong Yin(Anhui Medical University), Jinping Gao(Anhui University), Yujun Sheng(Anhui University), Jinhua Xu(Anhui Medical University), Jianzhong Zhang(Peking University), Chundi He(China Medical University), Ying Qiu(Jining First People's Hospital), Guangdong Wen(Peking University), Hongqing Tian(Shandong Provincial Institute of Dermatology and Venereology), Xiaodong Zheng(Anhui University), Shengxiu Liu(Anhui University), Wenjun Wang(Anhui University), Weiran Li(Anhui University), Yuyan Cheng(Anhui University), Longdan Liu(Anhui University), Yan Chang(Anhui University), Zaixing Wang(Anhui University), Zenggang Li(Anhui University), Longnian Li(Anhui University), Jianping Wu(Anhui University), Ling Fang(Anhui University), Changbing Shen(Anhui University), Fusheng Zhou(Anhui University), Bo Liang(Anhui University), Gang Chen(Anhui University), Hui Li(Anhui University), Yong Cui(Anhui University), Aie Xu(Third People's Hospital of Hangzhou), Xueqin Yang(Air Force General Hospital PLA), Fei Hao(Army Medical University), Limin Xu, Xing Fan(Anhui University), Yuzhen Li(Harbin Medical University), Rina Wu(Inner Mongolia Medical College Hospital), Xiuli Wang(Shanghai Skin Disease Hospital), Xiaoming Liu(Dalian Medical University), Min Zheng(Second Affiliated Hospital of Zhejiang University), Shunpeng Song(Dalian Dermatosis Hospital), JI Bi-hua(Wannan Medical College), Hong Fang(Zhejiang University), Jianbin Yu(First Affiliated Hospital of Zhengzhou University), Yongxin Sun(Tanggangzi hospital), Hui Yan(Xinjiang Medical University), Furen Zhang(Shandong Provincial Institute of Dermatology and Venereology), Rong Yang(The Military General Hospital of Beijing PLA), Sen Yang(Anhui University), Xuejun Zhang(Anhui Medical University)
Nature Communications
April 9, 2015
10.1038/ncomms7793
Cited by 150Open Access
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Abstract

Genome-wide association studies (GWASs) have reproducibly associated ∼40 susceptibility loci with psoriasis. However, the missing heritability is evident and the contributions of coding variants have not yet been systematically evaluated. Here, we present a large-scale whole-exome array analysis for psoriasis consisting of 42,760 individuals. We discover 16 SNPs within 15 new genes/loci associated with psoriasis, including C1orf141, ZNF683, TMC6, AIM2, IL1RL1, CASR, SON, ZFYVE16, MTHFR, CCDC129, ZNF143, AP5B1, SYNE2, IFNGR2 and 3q26.2-q27 (P<5.00 × 10(-08)). In addition, we also replicate four known susceptibility loci TNIP1, NFKBIA, IL12B and LCE3D-LCE3E. These susceptibility variants identified in the current study collectively account for 1.9% of the psoriasis heritability. The variant within AIM2 is predicted to impact protein structure. Our findings increase the number of genetic risk factors for psoriasis and highlight new and plausible biological pathways in psoriasis.

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