Dioxin in Soil: Bioavailability After Ingestion by Rats and Guinea Pigs
Ernest E. McConnell(National Institute of Environmental Health Sciences), George W. Lucier(National Institute of Environmental Health Sciences), Richard C. Rumbaugh(National Institute of Environmental Health Sciences), Phillip W. Albro(National Institute of Environmental Health Sciences), D. J. Harvan(National Institute of Environmental Health Sciences), J. Ronald Hass(National Institute of Environmental Health Sciences), Martha Harris(National Institute of Environmental Health Sciences)
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Abstract
Soil environmentally contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was given by gavage to guinea pigs and rats. The development of a characteristic clinicopathologic syndrome in guinea pigs, the induction of aryl hydrocarbon hydroxylase in rats, and the presence of TCDD in the livers of both species show that TCDD in soil exhibits high biological availability after ingestion.
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