Development of a Standard Reference Material for Metabolomics Research

Karen W. Phinney(National Institute of Standards and Technology), Guillaume Ballihaut(National Institute of Standards and Technology), Mary Bedner(National Institute of Standards and Technology), Brandi S. Benford(Material Measurement Laboratory), Johanna E Camara(Material Measurement Laboratory), Steven J. Christopher(Material Measurement Laboratory), William C. Davis(National Institute of Standards and Technology), Nathan G. Dodder(Material Measurement Laboratory), Gauthier Eppe(Material Measurement Laboratory), Brian E. Lang(National Institute of Standards and Technology), Stephen E. Long(Material Measurement Laboratory), Mark S. Lowenthal(Material Measurement Laboratory), Elizabeth A. McGaw(Material Measurement Laboratory), Karen E. Murphy(National Institute of Standards and Technology), Bryant C. Nelson(Material Measurement Laboratory), Jocelyn L. Prendergast(National Institute of Standards and Technology), Jessica L. Reiner(Material Measurement Laboratory), Catherine A. Rimmer(Material Measurement Laboratory), Lane C. Sander(Material Measurement Laboratory), Michele M. Schantz(National Institute of Standards and Technology), Katherine E. Sharpless(National Institute of Standards and Technology), Lorna T. Sniegoski(Material Measurement Laboratory), Susan S.-C. Tai(Material Measurement Laboratory), Jeanice B. Thomas(Material Measurement Laboratory), Thomas Vetter(Material Measurement Laboratory), Michael J. Welch(National Institute of Standards and Technology), Stephen A. Wise(Material Measurement Laboratory), Laura J. Wood(Material Measurement Laboratory), William F. Guthrie(National Institute of Standards and Technology), Charles Hagwood(National Institute of Standards and Technology), Stefan D. Leigh(National Institute of Standards and Technology), James H. Yen(National Institute of Standards and Technology), Nien‐Fan Zhang(National Institute of Standards and Technology), Madhu Chaudhary‐Webb(Centers for Disease Control and Prevention), Huiping Chen(Centers for Disease Control and Prevention), Zia Fazili(Centers for Disease Control and Prevention), Donna J. LaVoie(National Center for Environmental Health), Leslie F. McCoy(Centers for Disease Control and Prevention), Shahzad S. Momin(Centers for Disease Control and Prevention), Neelima Paladugula(Centers for Disease Control and Prevention), Elizabeth C Pendergrast(Centers for Disease Control and Prevention), Christine M Pfeiffer(Centers for Disease Control and Prevention), Carissa D. Powers(Centers for Disease Control and Prevention), Daniel Rabinowitz(Centers for Disease Control and Prevention), Michael E. Rybak(National Center for Environmental Health), Rosemary L. Schleicher(Centers for Disease Control and Prevention), Bridgette M. H. Toombs(National Center for Environmental Health), Mary Jue Xu(Centers for Disease Control and Prevention), Mindy Zhang(Centers for Disease Control and Prevention), Arthur L. Castle(National Institute of Diabetes and Digestive and Kidney Diseases)
Analytical Chemistry
November 4, 2013
10.1021/ac402689t
Cited by 138

Abstract

The National Institute of Standards and Technology (NIST), in collaboration with the National Institutes of Health (NIH), has developed a Standard Reference Material (SRM) to support technology development in metabolomics research. SRM 1950 Metabolites in Human Plasma is intended to have metabolite concentrations that are representative of those found in adult human plasma. The plasma used in the preparation of SRM 1950 was collected from both male and female donors, and donor ethnicity targets were selected based upon the ethnic makeup of the U.S. population. Metabolomics research is diverse in terms of both instrumentation and scientific goals. This SRM was designed to apply broadly to the field, not toward specific applications. Therefore, concentrations of approximately 100 analytes, including amino acids, fatty acids, trace elements, vitamins, hormones, selenoproteins, clinical markers, and perfluorinated compounds (PFCs), were determined. Value assignment measurements were performed by NIST and the Centers for Disease Control and Prevention (CDC). SRM 1950 is the first reference material developed specifically for metabolomics research.

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