Clinical Trials and Medical Care: Defining the Therapeutic Misconception

Gail E. Henderson, Larry R. Churchill(Vanderbilt University), Arlene M. Davis(University of North Carolina at Chapel Hill), Michele M. Easter, Christine Grady(National Institutes of Health), Steven Joffe(Harvard University Press), Nancy Kass, Nancy M. P. King(Wake Forest University), Charles W. Lidz(University of Massachusetts Boston), Franklin G. Miller(National Institutes of Health), Daniel K. Nelson(University of North Carolina at Chapel Hill), Jeffrey Peppercorn, Barbra Bluestone Rothschild, Pamela Sankar, Benjamin S. Wilfond(University of Washington), Catherine Zimmer
PLoS Medicine
November 20, 2007
Cited by 464Open Access
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Abstract

Summary Points:\nA key component of informed consent to participate in medical research is the understanding that research is not the same as treatment.\nHowever, studies have found that some research participants do not appreciate important differences between research and treatment, a phenomenon called “therapeutic misconception.”\nA consistent definition of therapeutic misconception is missing from the literature, and this hinders attempts to define its prevalence or ways to reduce it.\nThis paper proposes a new definition and describes how it can be operationalized.


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