Assessment, Diagnosis, and Treatment of HIV-Associated Neurocognitive Disorder: A Consensus Report of the Mind Exchange Program

The Mind Exchange Working Group, Andrea Antinori(Heinrich Heine University Düsseldorf), Gabriele Arendt(University of California San Diego), Igor Grant(University of California San Diego), Scott Letendre, Chair(Universitat Autònoma de Barcelona), José A. Muñoz-Moreno(University of California San Diego), Christian Eggers, Bruce J. Brew, Marie‐Josée Brouillette, Francisco Bernal-Cano, Adriana Carvalhal, Paulo Pereira Christo, Paola Cinque(University of California San Diego), Lucette A. Cysique(University of California San Diego), Ronald J. Ellis, I. Everall, J. Gasnault, I. W. Husstedt, Volkan Korten(University of California San Diego), Ladislav Machala, Mark Obermann(University of California San Diego), Sílvia Ouakinin(University of California San Diego), D Podzamczer, Peter Portegies(University of California San Diego), Simon Rackstraw(University of California San Diego), Sean B. Rourke(University of California San Diego), Lorraine Sherr, Adrian Streinu‐Cercel, Alan Winston, Valerie Wojna, Y. Yazdanpannah, Gordon Arbess, J.-G. Baril, Josip Begovać(University of California San Diego), Colm Bergin, Paolo Bonfanti(University of California San Diego), Stefano Bonora, Kees Brinkman, Ana Canestri, G. Cholewinska-Szymanska, Michal Chowers, Jeffrey W. Cooney, Marcelo Corti(University of California San Diego), Colin P. Doherty(University of California San Diego), Daniel Elbirt(University of California San Diego), S. Esser(University of California San Diego), Éric Florence, Gilles Force, M. John Gill, Jean‐Christophe Goffard(University of California San Diego), Thomas Harrer, Pengyuan Li, L. V. de Kerckhove, G. Knecht(University of California San Diego), Shuzo Matsushita(University of California San Diego), Raimonda Matulionytė(University of California San Diego), Samuel McConkey, A. Mouglignier(University of California San Diego), Shinichi Oka, Augusto Penalva, Klaris Riesenberg, Helen Sambatakou, Valerio Tozzi, Matteo Vassallo, Peter Wetterberg, A. W. Drapato
Clinical Infectious Diseases
November 21, 2012
10.1093/cid/cis975
Cited by 207Open Access
Full Text

Abstract

Many practical clinical questions regarding the management of human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) remain unanswered. We sought to identify and develop practical answers to key clinical questions in HAND management. Sixty-six specialists from 30 countries provided input into the program, which was overseen by a steering committee. Fourteen questions were rated as being of greatest clinical importance. Answers were drafted by an expert group based on a comprehensive literature review. Sixty-three experts convened to determine consensus and level of evidence for the answers. Consensus was reached on all answers. For instance, good practice suggests that all HIV patients should be screened for HAND early in disease using standardized tools. Follow-up frequency depends on whether HAND is already present or whether clinical data suggest risk for developing HAND. Worsening neurocognitive impairment may trigger consideration of antiretroviral modification when other causes have been excluded. The Mind Exchange program provides practical guidance in the diagnosis, monitoring, and treatment of HAND.

Related Papers

No related papers found

Powered by citation graph analysis