The PIK3CA gene is mutated with high frequency in human breast cancers
Kurtis E. Bachman(Johns Hopkins University), Pedram Argani, Yardena Samuels(Johns Hopkins University), Natalie Silliman(Johns Hopkins University), Janine Ptak(Johns Hopkins University), Steve Szabo(Johns Hopkins University), Hiroyuki Konishi(Johns Hopkins University), Bedri Karakas(Johns Hopkins University), Brian Blair(Johns Hopkins University), Clarence Lin(Johns Hopkins University), Brock A. Peters(Johns Hopkins University), Victor E. Velculescu, Ben Ho Park(Yahoo (United Kingdom))
Cited by 664Open Access
Abstract
The phosphatidylinositol 3-kinases (PI3Ks) are known regulators of cellular growth and proliferation. It has recently been reported that somatic mutations within the PI3K subunit p110alpha (PIK3CA) are present in human colorectal and other cancers. Here we show that thirteen of fifty-three breast cancers (25%) contain somatic mutations in PIK3CA, with the majority of mutations located in the kinase domain. These results demonstrate that PIK3CA is the most mutated oncogene in breast cancer and support a role for PIK3CA in epithelial carcinogenesis.
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