Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways
Lisa M. Coussens(Atotech (United States)), Peter J. Parker(The Honourable Society of Lincoln's Inn), Lucy Rhee(Atotech (United States)), Teresa L. Yang‐Feng(Yale University), Ellson Chen(Atotech (United States)), Michael D. Waterfield(The Honourable Society of Lincoln's Inn), Uta Francke(Yale University), Axel Ullrich(Atotech (United States))
Cited by 1,051
Abstract
A new family of protein kinase C-related genes has been identified in bovine, human, and rat genomes. The alpha-, beta-, and gamma-type protein kinase sequences are highly homologous, include a kinase domain, and potential calcium-binding sites, and they contain interspersed variable regions. The corresponding genes are located on distinct human chromosomes; the possibility of even greater genetic complexity of this gene family is suggested by Northern and Southern hybridization analyses.
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