The Cloning of PIG-A, a Component in the Early Step of GPI-Anchor Biosynthesis
Toshio Miyata(The University of Osaka), Junji Takeda(The University of Osaka), Yoshiyasu Iida(Nagoya University Hospital), Norio Yamada(Nagoya University Hospital), Norimitsu Inoue(Gifu University), Minoru Takahashi(The University of Osaka), Kenji Maeda(Nagoya University Hospital), Teruo Kitani(The University of Osaka), Taroh Kinoshita(The University of Osaka)
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Abstract
The glycosylphosphatidylinositol (GPI) anchor is a membrane attachment structure of many proteins and occurs in a wide variety of eukaryotes from yeasts to mammals. The structure of the core of the GPI anchor is conserved in protozoa and mammals and so is its biosynthetic pathway. A complementary DNA encoding a human protein termed PIG-A (phosphatidylinositol glycan-class A) was cloned. PIG-A was necessary for synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.
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