Intracellular heterogeneity in mitochondrial membrane potentials revealed by a J-aggregate-forming lipophilic cation JC-1.
S T Smiley(Harvard University), Martin Reers(Harvard University), C Mottola-Hartshorn(Harvard University), Michael F. Lin(Harvard University), Aileen B. Chen(Harvard University), Thomas W. Smith(Harvard University), G Steele(Harvard University), L B Chen(Harvard University)
Cited by 1,636Open Access
Abstract
By using a potential-dependent J-aggregate-forming delocalized lipophilic cation, 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine++ + iodide (JC-1), we find that membrane potentials across mitochondria in a living cell can be heterogeneous. Remarkably, even within a long contiguous mitochondrion, regional heterogeneity in membrane potentials appears to be possible.
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