Coupling Between Neuronal Firing, Field Potentials, and fMRI in Human Auditory Cortex

Roy Mukamel(University of California, Los Angeles), Hagar Gelbard(University of California, Los Angeles), Amos Arieli(University of California, Los Angeles), Uri Hasson(University of California, Los Angeles), Itzhak Fried(University of California, Los Angeles), Rafael Malach(University of California, Los Angeles)
Science
August 4, 2005
10.1126/science.1110913
Cited by 1,085

Abstract

Functional magnetic resonance imaging (fMRI) is an important tool for investigating human brain function, but the relationship between the hemodynamically based fMRI signals in the human brain and the underlying neuronal activity is unclear. We recorded single unit activity and local field potentials in auditory cortex of two neurosurgical patients and compared them with the fMRI signals of 11 healthy subjects during presentation of an identical movie segment. The predicted fMRI signals derived from single units and the measured fMRI signals from auditory cortex showed a highly significant correlation (r = 0.75, P < 10(-47)). Thus, fMRI signals can provide a reliable measure of the firing rate of human cortical neurons.

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