Immunostimulating hexapeptide from human casein: amino acid sequence, synthesis and biological properties
Fabienne Parker(Centre National de la Recherche Scientifique), D. Migliore-Samour(Centre National de la Recherche Scientifique), François Floc’h(Smiths Detection (France)), Aurelio Zerial(Smiths Detection (France)), Georges H. Werner(Smiths Detection (France)), P. Jollès(Centre National de la Recherche Scientifique), M. Casaretto(Westfälische Hochschule), Helmut Zahn(Westfälische Hochschule), Pierre JOLLES(Centre National de la Recherche Scientifique)
Cited by 174Open Access
Abstract
A hexapeptide obtained from human casein by enzymatic digestion has been purified, sequenced and synthesized; its structure is: Val-Glu-Pro-Ile-Pro-Tyr. In vitro this hexapeptide stimulates the phagocytosis of opsonized sheep red blood cells by murine peritoneal macrophages. Administered intravenously to adult mice, it enhances the resistance to infection with Klebsiella pneumoniae.
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