Decreased Regional Cerebral Metabolic Rate for Glucose in Systemic Lupus erythematosus Patients with Psychiatric Symptoms

Naoya Komatsu(Chiba University), Kazuhiro Kodama(Moscow Research and Clinical Center for Neuropsychiatry), Naoto Yamanouchi(Moscow Research and Clinical Center for Neuropsychiatry), Shinichi Okada(Moscow Research and Clinical Center for Neuropsychiatry), Shingo Noda(Moscow Research and Clinical Center for Neuropsychiatry), Yasushi Nawata(Second Hospital of Nanchang), Katsuhiko Takabayashi(Second Hospital of Nanchang), Itsuo Iwamoto(Second Hospital of Nanchang), Yasushi Saitō(Second Hospital of Nanchang), Yoshitaka Uchida(Chiba University), Hisashi Ito(Chiba University), Kyosan Yoshikawa, Toshio Sato(Moscow Research and Clinical Center for Neuropsychiatry)
European Neurology
January 1, 1999
10.1159/000008067
Cited by 52

Abstract

To determine brain functional abnormality in systemic lupus erythematosus (SLE) patients with psychiatric symptoms, we evaluated 12 active SLE patients with or without psychiatric symptoms by means of [18F]2-fluoro-2-deoxy-D-glucose positron emission tomography (PET), magnetic resonance imaging and neuropsychological testing. Patients with psychiatric symptoms showed significantly poorer performance in tests which subserved attentional function. The PET study revealed that the psychiatric patients had significantly decreased regional cerebral metabolic rates for glucose in the prefrontal, inferior parietal and anterior cingulate regions. Prefrontal, inferior parietal and anterior cingulate dysfunction may be related to attentional deficits that are involved in various psychiatric symptoms in SLE. PET is an invaluable tool to reveal such brain functional abnormality seen in SLE patients with psychiatric symptoms.

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