Evidence for a primary association of celiac disease to a particular HLA-DQ alpha/beta heterodimer.
Ludvig M. Sollid(Oslo University Hospital), G. Markussen(Oslo University Hospital), J. Ek(Oslo University Hospital), Hallvard Gjerde(Oslo University Hospital), Frode Vartdal(Oslo University Hospital), Erik Thorsby(Oslo University Hospital)
Cited by 939Open Access
Abstract
Typing of DNA from 94 unrelated children with celiac disease (CD) with HLA-DQA1 and -DQB1 allele-specific oligonucleotide probes revealed that all but one (i.e., 98.9%) may share a particular combination of a DQA1 and a DQB1 gene. These genes are arranged in cis position on the DR3DQw2 haplotype and in trans position in DR5DQw7/DR7DQw2 heterozygous individuals. Thus, most CD patients may share the same cis- or trans-encoded HLA-DQ alpha/beta heterodimer.
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