Expression of Interleukin-10 Activity by Epstein-Barr Virus Protein BCRF1
Di‐Hwei Hsu(Palo Alto Research Center), René de Waal Malefyt(Institut de Biologie Moléculaire et Cellulaire), David Fiorentino(Palo Alto Research Center), M N Dang(Palo Alto Research Center), Paulo Vieira(Palo Alto Research Center), J Devriès(Institut de Biologie Moléculaire et Cellulaire), Hergen Spits(Institut de Biologie Moléculaire et Cellulaire), Timothy R. Mosmann(Palo Alto Research Center), Kevin W. Moore(Palo Alto Research Center)
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Abstract
Cytokine synthesis inhibitory factor (CSIF; interleukin-10), a product of mouse TH2 T cell clones that inhibits synthesis of cytokines by mouse TH1 T cell clones, exhibits extensive sequence similarity to an uncharacterized open reading frame in the Epstein-Barr virus BCRF1. Recombinant BCRF1 protein mimics the activity of interleukin-10, suggesting that BCRF1 may have a role in the interaction of the virus with the host's immune system.
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