Topographical and Temporal Diversity of the Human Skin Microbiome
Elizabeth A. Grice(National Human Genome Research Institute), Heidi H. Kong(National Cancer Institute), Sean Conlan(National Human Genome Research Institute), Clayton Deming(National Human Genome Research Institute), Joie Davis(National Human Genome Research Institute), Alice Young(National Human Genome Research Institute), NISC Comparative Sequencing Program(National Human Genome Research Institute), Gerard G. Bouffard(National Human Genome Research Institute), Robert W. Blakesley(National Human Genome Research Institute), Patrick R. Murray(National Human Genome Research Institute), Eric D. Green(National Human Genome Research Institute), Maria L. Turner(National Human Genome Research Institute), Julia A. Segre(National Human Genome Research Institute)
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Abstract
Human skin is a large, heterogeneous organ that protects the body from pathogens while sustaining microorganisms that influence human health and disease. Our analysis of 16S ribosomal RNA gene sequences obtained from 20 distinct skin sites of healthy humans revealed that physiologically comparable sites harbor similar bacterial communities. The complexity and stability of the microbial community are dependent on the specific characteristics of the skin site. This topographical and temporal survey provides a baseline for studies that examine the role of bacterial communities in disease states and the microbial interdependencies required to maintain healthy skin.
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