PEGylated WS<sub>2</sub> Nanosheets as a Multifunctional Theranostic Agent for in vivo Dual‐Modal CT/Photoacoustic Imaging Guided Photothermal Therapy
Liang Cheng(Soochow University), Jingjing Liu(Soochow University), Xing Gu(Soochow University), Hua Gong(Soochow University), Xiaoze Shi(Soochow University), Teng Liu(Soochow University), Chao Wang(Soochow University), Xiaoyong Wang(Xiamen University), Gang Liu(Xiamen University), Huaiyong Xing(Chinese Academy of Sciences), Wenbo Bu(Chinese Academy of Sciences), Baoquan Sun(Soochow University), Zhuang Liu(Soochow University)
Cited by 1,099
Abstract
A new generation of photothermal theranostic agents is developed based on PEGylated WS2 nanosheets. Bimodal in vivo CT/photoacoustic imaging reveals strong tumor contrast after either intratumoral or intravenous injection of WS2 -PEG. In vivo photothermal treatment is then conducted in a mouse tumor model, achieving excellent therapeutic efficacy with complete ablation of tumors. This work promises further exploration of transition-metal dichalcogenides for biomedical applications, such as cancer imaging and therapy.
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