Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Paul R. Burton; Martin D. Tobin; Paul R Burton; John R. Thompson; Paul R Burton; David Clayton; H. E. Stevens; Kate Downes; David G Clayton; David B Dunger; Sarah Nutland; David G Clayton; H.T. Leung; Barry Widmer; John A. Todd; Neil Walker; Andrew P. Morris; David M. Evans; Kate Elliott; Lon R Cardon; Eleftheria Zeggini; Emily Lyons; Yik Ying Teo; Jeffrey C. Barrett; Dominic P Kwiatkowski; Dominic P Kwiatkowski; Nicolas J Timpson; Mark I McCarthy; Nigel W Rayner; Fredrik Vannberg; Adrian V. S. Hill; Cecilia M. Lindgren; Kirk A. Rockett; Lon R Cardon; Nick Craddock; David Withers; Mohammed J. R. Ghori; Panos Deloukas; Andrew Keniry; Rathi Ravindrarajah; Amy Chaney; Claire Widden; Panos Deloukas; Dominic P Kwiatkowski; Andrew Keniry; Antony P Attwood; Ralph McGinnis; Kate Downes; Simon Potter; Suzannah J. Bumpstead; Panos Deloukas; Sarah Hunt; Rhian Gwilliam; Emma King; Ralph McGinnis; Michael Inouye; Pamela Whittaker; David Bentley; Audrey Duncanson; Mark I. McCarthy; Kate Elliott; Eleftheria Zeggini; Christopher J. Groves; Nigel W Rayner; Mark I. McCarthy; Mark I McCarthy; Cecilia M. Lindgren; James P Boorman; Niall Taylor; Kerstin Koch; Willem H Ouwehand; Nicholas A. Watkins; Thilo Winzer; Willem H Ouwehand; Antony P Attwood; Jennifer D. Jolley; Willem H Ouwehand; Barbara Cant; Alexandra S. Knight; James P Boorman; Willem H Ouwehand; Nicholas A. Watkins; Willem H Ouwehand; Willem H Ouwehand; Nilesh J Samani; Richard J. Dixon; Nilesh J. Samani; Massimo Mangino; Nilesh J Samani; Suzanne Stevens; Peter S. Braund; Peter Donnelly; Niall J. Cardin; Chris C. A. Spencer; Damjan Vukcevic; Jonathan Marchini; Joanne Pereira-Gale; Dan Davison; Ingeleif B Hallgrimsdóttir; Yik Ying Teo; Bryan Howie; Teresa Ferreira; Zhan Su; Peter Donnelly; Doug Easton; Doug Easton; Ursula Everson; Judith M. Hussey; Elizabeth Meech; C V Prowse; Graham R. Walters; Marcus Pembrey; Wendy L. McArdle; Richard W. Jones; Marcus Pembrey; Susan M. Ring; David P. Strachan; Marcus Pembrey; Marcus Pembrey; Gerome Breen; David St Clair; Sian Caesar; Katharine Gordon-Smith; Lisa Jones; Ian Jones; Elaine Green; Valentina Moskivina; Nick Craddock; Michael J. Owen; Ivan Nikolov; Nick Craddock; Marian L. Hamshere; Detelina Grozeva; Christine Fraser; Michael O‘Donovan; George Kirov; Peter Holmans; Katharine Gordon-Smith; David Collier; Peter McGuffin; Amanda Elkin; Richard Williamson; Anne Farmer; I. Nicol Ferrier; Allan H. Young; Mark M. Iles; Azhar Maqbool; D. Timothy Bishop; Anthony J. Balmforth; Nadira Yuldasheva; Alistair S. Hall; Stephen G. Ball; Jennifer H. Barrett; Alistair S. Hall; Mark Tremelling; Francesca Bredin; Miles Parkes; Miles Parkes; Elaine R. Nimmo; Hazel E. Drummond; Charles W Lees; Jack Satsangi; Christopher G Matthew; Natalie J. Prescott; Cathryn M. Lewis; Clive M. Onnie; Christopher G Matthew; Sheila Fisher; Alastair Forbes; Jeremy Sanderson; John Mansfield; Mohamed Khalid Mohiuddin; Jamie Barbour; Catherine E Todhunter; Fraser Cummings; Tariq Ahmad; Derek P. Jewell; John Webster; Morris J Brown; Mark G. Lathrop; John Connell; Anna F. Dominiczak; Mark Caulfield; Richard Dobson; Beverley Burke; Mark Caulfield; C Marcano; Mingzhan Xue; Patricia B. Munroe; Johannie Gungadoo; Kate Lee; Chris Wallace; Abiodun Onipinla; Stephen Newhouse; Martin Farrall; Martin Farrall; Deborah Symmons; Ian N Bruce; Sally John; Catherine Potter; Anne Hinks; Anne Barton; Jane Worthington; Samantha L Hilder; Hannah Donovan; Jane Worthington; Wendy Thomson; Paul Gilbert; Steve Eyre; Alan J. Silman; Barry Widmer; David B Dunger; Michael N Weedon; Andrew T Hattersley; Rachel M Freathy; Andrew T Hattersley; Hana Lango; John R B Perry; Timothy M Frayling; Michael N Weedon; Andrew T Hattersley; Rachel M Freathy; Beverley M. Shields; Andrew T Hattersley; Hana Lango; John R B Perry; Timothy M Frayling; G. A. Hitman; Mark Walker; Nicolas J Timpson; Giorgio Sirugo; David J. Conway; Melanie J. Newport; Melanie J. Newport; Muminatou Jallow; Matthew A Brown; Linda A Bradbury; Matthew A Brown; Paul Wordsworth; Jennifer J. Pointon; Matthew A Brown; Matthew A. Brown; Claire Farrar; Paul Newby; Jackie Carr‐Smith; Stephan Brand; Stephen CL Gough; Stephen C L Gough; Matthew J. Simmonds; J. M. Heward; Jayne A. Franklyn; Sarah L Mitchell; Nazneen Rahman; Sheila Seal; Nazneen Rahman; Michael R. Stratton; Michael R Stratton; Michael R. Stratton; Stephen Sawcer; An Goris; Alastair Compston; Alastair Compston; Maria Ban; David Bentley; Lon R. Cardon; Lon R Cardon; Lon R Cardon; Simon H. S. Pearce; John D. Reveille; Xiaodong Zhou; Linda A Bradbury; Jacqueline Taylor; Alison Dowling; Anne-Marie Sims; Matthew A Brown; Tracy Doan; Lon R. Cardon; John C. Davis; Matthew A Brown; Paul Wordsworth; Jennifer J. Pointon; Laurie Savage; Michael M. Ward; Thomas L Learch; Michael H. Weisman

doi:10.1038/ng.2007.17

Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants

Paul R. Burton(University of Leicester), Martin D. Tobin(University of Leicester), Paul R Burton (University of Leicester), John R. Thompson(University of Leicester), Paul R Burton(University of Leicester), David Clayton(Juvenile Diabetes Research Foundation), H. E. Stevens(Juvenile Diabetes Research Foundation), Kate Downes(Wellcome Sanger Institute), David G Clayton(Juvenile Diabetes Research Foundation), David B Dunger(University of Cambridge), Sarah Nutland(Juvenile Diabetes Research Foundation), David G Clayton (Juvenile Diabetes Research Foundation), H.T. Leung(Juvenile Diabetes Research Foundation), Barry Widmer(University of Cambridge), John A. Todd(Juvenile Diabetes Research Foundation), Neil Walker(Juvenile Diabetes Research Foundation), Andrew P. Morris(Centre for Human Genetics), David M. Evans(Centre for Human Genetics), Kate Elliott(Centre for Human Genetics), Lon R Cardon(Centre for Human Genetics), Eleftheria Zeggini(Centre for Human Genetics), Emily Lyons(Centre for Human Genetics), Yik Ying Teo(Centre for Human Genetics), Jeffrey C. Barrett(University of Leeds), Dominic P Kwiatkowski (Centre for Human Genetics), Dominic P Kwiatkowski(Centre for Human Genetics), Nicolas J Timpson(Centre for Human Genetics), Mark I McCarthy(Centre for Human Genetics), Nigel W Rayner(Centre for Human Genetics), Fredrik Vannberg(Centre for Human Genetics), Adrian V. S. Hill(Centre for Human Genetics), Cecilia M. Lindgren(Centre for Human Genetics), Kirk A. Rockett(Centre for Human Genetics), Lon R Cardon(Centre for Human Genetics), Nick Craddock(Cardiff University), David Withers(Wellcome Sanger Institute), Mohammed J. R. Ghori(Wellcome Sanger Institute), Panos Deloukas(Wellcome Sanger Institute), Andrew Keniry(Wellcome Sanger Institute), Rathi Ravindrarajah(Wellcome Sanger Institute), Amy Chaney(Wellcome Sanger Institute), Claire Widden(Wellcome Sanger Institute), Panos Deloukas(Wellcome Sanger Institute), Dominic P Kwiatkowski(Centre for Human Genetics), Andrew Keniry(Wellcome Sanger Institute), Antony P Attwood(University of Cambridge), Ralph McGinnis(Wellcome Sanger Institute), Kate Downes(Wellcome Sanger Institute), Simon Potter(Wellcome Sanger Institute), Suzannah J. Bumpstead(Wellcome Sanger Institute), Panos Deloukas(Wellcome Sanger Institute), Sarah Hunt(Wellcome Sanger Institute), Rhian Gwilliam(Wellcome Sanger Institute), Emma King(Wellcome Sanger Institute), Ralph McGinnis(Wellcome Sanger Institute), Michael Inouye(Wellcome Sanger Institute), Pamela Whittaker(Wellcome Sanger Institute), David Bentley(Wellcome Sanger Institute), Audrey Duncanson(Wellcome Trust), Mark I. McCarthy(Centre for Human Genetics), Kate Elliott(Centre for Human Genetics), Eleftheria Zeggini(Centre for Human Genetics), Christopher J. Groves(Churchill Hospital), Nigel W Rayner(Centre for Human Genetics), Mark I. McCarthy(Centre for Human Genetics), Mark I McCarthy (Centre for Human Genetics), Cecilia M. Lindgren(Centre for Human Genetics), James P Boorman(NHS Blood and Transplant), Niall Taylor(University of Cambridge), Kerstin Koch(University of Cambridge), Willem H Ouwehand(NHS Blood and Transplant), Nicholas A. Watkins(NHS Blood and Transplant), Thilo Winzer(University of Cambridge), Willem H Ouwehand (NHS Blood and Transplant), Antony P Attwood(University of Cambridge), Jennifer D. Jolley(University of Cambridge), Willem H Ouwehand(NHS Blood and Transplant), Barbara Cant(University of Cambridge), Alexandra S. Knight(University of Cambridge), James P Boorman(NHS Blood and Transplant), Willem H Ouwehand(NHS Blood and Transplant), Nicholas A. Watkins(NHS Blood and Transplant), Willem H Ouwehand (NHS Blood and Transplant), Willem H Ouwehand(NHS Blood and Transplant), Nilesh J Samani(Glenfield Hospital), Richard J. Dixon(Glenfield Hospital), Nilesh J. Samani(Glenfield Hospital), Massimo Mangino(Glenfield Hospital), Nilesh J Samani (Glenfield Hospital), Suzanne Stevens(Glenfield Hospital), Peter S. Braund(Glenfield Hospital), Peter Donnelly(University of Oxford), Niall J. Cardin(University of Oxford), Chris C. A. Spencer(University of Oxford), Damjan Vukcevic(University of Oxford), Jonathan Marchini(University of Oxford), Joanne Pereira-Gale(University of Oxford), Dan Davison(University of Oxford), Ingeleif B Hallgrimsdóttir(University of Oxford), Yik Ying Teo(Centre for Human Genetics), Bryan Howie(University of Oxford), Teresa Ferreira(University of Oxford), Zhan Su(University of Oxford), Peter Donnelly(University of Oxford), Doug Easton(Cancer Research UK), Doug Easton (Cancer Research UK), Ursula Everson(NHS Blood and Transplant), Judith M. Hussey(Brentwood Community Hospital), Elizabeth Meech(Welsh Government), C V Prowse(Scottish National Blood Transfusion Service), Graham R. Walters(NHS Blood and Transplant), Marcus Pembrey(University of Bristol), Wendy L. McArdle(University of Bristol), Richard W. Jones(University of Bristol), Marcus Pembrey(University of Bristol), Susan M. Ring(University of Bristol), David P. Strachan(St George's, University of London), Marcus Pembrey(University of Bristol), Marcus Pembrey (University of Bristol), Gerome Breen(University of Aberdeen), David St Clair(University of Aberdeen), Sian Caesar(University of Birmingham), Katharine Gordon-Smith(Cardiff University), Lisa Jones(University of Birmingham), Ian Jones(Cardiff University), Elaine Green(Cardiff University), Valentina Moskivina(Cardiff University), Nick Craddock(Cardiff University), Michael J. Owen(Cardiff University), Ivan Nikolov(Cardiff University), Nick Craddock (Cardiff University), Marian L. Hamshere(Cardiff University), Detelina Grozeva(Cardiff University), Christine Fraser(Cardiff University), Michael O‘Donovan(Cardiff University), George Kirov(Cardiff University), Peter Holmans(Cardiff University), Katharine Gordon-Smith(Cardiff University), David Collier(King's College London), Peter McGuffin(King's College London), Amanda Elkin(King's College London), Richard Williamson(King's College London), Anne Farmer(King's College London), I. Nicol Ferrier(Royal Victoria Infirmary), Allan H. Young(Royal Victoria Infirmary), Mark M. Iles(University of Leeds), Azhar Maqbool(University of Leeds), D. Timothy Bishop(University of Leeds), Anthony J. Balmforth(University of Leeds), Nadira Yuldasheva(University of Leeds), Alistair S. Hall(University of Leeds), Stephen G. Ball(University of Leeds), Jennifer H. Barrett(University of Leeds), Alistair S. Hall(University of Leeds), Mark Tremelling(Addenbrooke's Hospital), Francesca Bredin(Addenbrooke's Hospital), Miles Parkes(Addenbrooke's Hospital), Miles Parkes (Addenbrooke's Hospital), Elaine R. Nimmo(Western General Hospital), Hazel E. Drummond(Western General Hospital), Charles W Lees(Western General Hospital), Jack Satsangi(Western General Hospital), Christopher G Matthew(Guy's Hospital), Natalie J. Prescott(Guy's Hospital), Cathryn M. Lewis(Guy's Hospital), Clive M. Onnie(Guy's Hospital), Christopher G Matthew(Guy's Hospital), Sheila Fisher(Guy's Hospital), Alastair Forbes(University College London), Jeremy Sanderson(Guy's and St Thomas' NHS Foundation Trust), John Mansfield(Royal Victoria Infirmary), Mohamed Khalid Mohiuddin(Royal Victoria Infirmary), Jamie Barbour(Royal Victoria Infirmary), Catherine E Todhunter(Royal Victoria Infirmary), Fraser Cummings(University of Oxford), Tariq Ahmad(University of Oxford), Derek P. Jewell(University of Oxford), John Webster(Aberdeen Royal Infirmary), Morris J Brown(Princess Alexandra Hospital), Mark G. Lathrop(Centre National de Recherche en Génomique Humaine), John Connell(University of Glasgow), Anna F. Dominiczak(University of Glasgow), Mark Caulfield(William Harvey Research Institute), Richard Dobson(William Harvey Research Institute), Beverley Burke(William Harvey Research Institute), Mark Caulfield (William Harvey Research Institute), C Marcano(William Harvey Research Institute), Mingzhan Xue(William Harvey Research Institute), Patricia B. Munroe(William Harvey Research Institute), Johannie Gungadoo(William Harvey Research Institute), Kate Lee(William Harvey Research Institute), Chris Wallace(William Harvey Research Institute), Abiodun Onipinla(William Harvey Research Institute), Stephen Newhouse(William Harvey Research Institute), Martin Farrall(Centre for Human Genetics), Martin Farrall (Centre for Human Genetics), Deborah Symmons(University of Manchester), Ian N Bruce(University of Manchester), Sally John(University of Manchester), Catherine Potter(University of Manchester), Anne Hinks(University of Manchester), Anne Barton(University of Manchester), Jane Worthington(University of Manchester), Samantha L Hilder(University of Manchester), Hannah Donovan(University of Manchester), Jane Worthington(University of Manchester), Wendy Thomson(University of Manchester), Paul Gilbert(University of Manchester), Steve Eyre(University of Manchester), Alan J. Silman(University of Manchester), Barry Widmer(University of Cambridge), David B Dunger (University of Cambridge), Michael N Weedon(Peninsula College of Medicine and Dentistry), Andrew T Hattersley (Peninsula College of Medicine and Dentistry), Rachel M Freathy(Peninsula College of Medicine and Dentistry), Andrew T Hattersley(Peninsula College of Medicine and Dentistry), Hana Lango(Peninsula College of Medicine and Dentistry), John R B Perry(Peninsula College of Medicine and Dentistry), Timothy M Frayling(Peninsula College of Medicine and Dentistry), Michael N Weedon(Peninsula College of Medicine and Dentistry), Andrew T Hattersley (Peninsula College of Medicine and Dentistry), Rachel M Freathy(Peninsula College of Medicine and Dentistry), Beverley M. Shields(Peninsula College of Medicine and Dentistry), Andrew T Hattersley(Peninsula College of Medicine and Dentistry), Hana Lango(Peninsula College of Medicine and Dentistry), John R B Perry(Peninsula College of Medicine and Dentistry), Timothy M Frayling(Peninsula College of Medicine and Dentistry), G. A. Hitman(Royal London Hospital), Mark Walker(Newcastle University), Nicolas J Timpson(Centre for Human Genetics), Giorgio Sirugo(MRC Unit the Gambia), David J. Conway(MRC Unit the Gambia), Melanie J. Newport(MRC Unit the Gambia), Melanie J. Newport(MRC Unit the Gambia), Muminatou Jallow(MRC Unit the Gambia), Matthew A Brown(Princess Alexandra Hospital), Linda A Bradbury(Princess Alexandra Hospital), Matthew A Brown (Princess Alexandra Hospital), Paul Wordsworth(University of Oxford), Jennifer J. Pointon(University of Oxford), Matthew A Brown(Princess Alexandra Hospital), Matthew A. Brown(Princess Alexandra Hospital), Claire Farrar(University of Oxford), Paul Newby(University of Birmingham), Jackie Carr‐Smith(University of Birmingham), Stephan Brand(University of Birmingham), Stephen CL Gough(University of Birmingham), Stephen C L Gough(University of Birmingham), Matthew J. Simmonds(University of Birmingham), J. M. Heward(University of Birmingham), Jayne A. Franklyn(University of Birmingham), Sarah L Mitchell(University of Birmingham), Nazneen Rahman(Institute of Cancer Research), Sheila Seal(Institute of Cancer Research), Nazneen Rahman (Institute of Cancer Research), Michael R. Stratton(Institute of Cancer Research), Michael R Stratton(Institute of Cancer Research), Michael R. Stratton(Institute of Cancer Research), Stephen Sawcer(University of Cambridge), An Goris(University of Cambridge), Alastair Compston(University of Cambridge), Alastair Compston(University of Cambridge), Maria Ban(University of Cambridge), David Bentley(Wellcome Sanger Institute), Lon R. Cardon(Centre for Human Genetics), Lon R Cardon (Centre for Human Genetics), Lon R Cardon(Centre for Human Genetics), Simon H. S. Pearce(Centre for Life), John D. Reveille(Texas Medical Center), Xiaodong Zhou(Texas Medical Center), Linda A Bradbury(Princess Alexandra Hospital), Jacqueline Taylor(Centre for Cancer Biology), Alison Dowling(Centre for Cancer Biology), Anne-Marie Sims(Centre for Cancer Biology), Matthew A Brown(Princess Alexandra Hospital), Tracy Doan(Centre for Cancer Biology), Lon R. Cardon(Centre for Human Genetics), John C. Davis(University of California, San Francisco), Matthew A Brown(Princess Alexandra Hospital), Paul Wordsworth (University of Oxford), Jennifer J. Pointon(University of Oxford), Laurie Savage(Spondylitis Association of America), Michael M. Ward(National Institute of Arthritis and Musculoskeletal and Skin Diseases), Thomas L Learch(Cedars-Sinai Medical Center), Michael H. Weisman(Cedars-Sinai Medical Center)

Nature Genetics

October 21, 2007

10.1038/ng.2007.17

Cited by 1,374Open Access

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