Table of new antiepileptic drugs

Abstract

Rufinamide (Banzel) For Lennox-Gastaut syndrome Adults:400-800 mg/day in 2 divided doses Peds: 4-10mg/kg/day in 2 divided doses Adults: 3200 mg/day in 2 divided doses Pediatrics: 45 mg/kg/day or 3200mg/kg/day in 2 divided doses Dose – dependent: fatigue, sedation, HA, gait changes, nausea, vomiting Shortening of QT interval May increase PHT, PB, and CBZ; May be decreased by PHT, PB, CBZ; decreased efficacy of oral contraceptives