Cloning of a Delta Opioid Receptor by Functional Expression
Christopher J. Evans(University of California, Los Angeles), Duane E. Keith(University of California, Los Angeles), Heather Morrison(University of California, Los Angeles), Karin Magendzo(University of California, Los Angeles), Robert H. Edwards(University of California, Los Angeles)
Cited by 1,225
Abstract
Opiate drugs have potent analgesic and addictive properties. These drugs interact with receptors that also mediate the response to endogenous opioid peptide ligands. However, the receptors for opioids have eluded definitive molecular characterization. By transient expression in COS cells and screening with an iodinated analog of the opioid peptide enkephalin, a complementary DNA clone encoding a functional delta opioid receptor has been identified. The sequence shows homology to G protein-coupled receptors, in particular the receptors for somatostatin, angiotensin, and interleukin-8.
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