Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line
Susan P. Lees‐Miller(University of Calgary), Roseline Godbout(University of Calgary), Doug W. Chan(University of Calgary), Michael Weinfeld(University of Calgary), Rufus S. Day(University of Calgary), Geraldine M. Barron(University of Calgary), Joan Allalunis‐Turner(University of Calgary)
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Abstract
The radiosensitive rodent mutant cell line xrs-5 is defective in DNA double-strand break repair and lacks the Ku component of the DNA-activated protein kinase, DNA-PK. Here radiosensitive human cell lines were analyzed for DNA-PK activity and for the presence of related proteins. The radiosensitive human malignant glioma M059J cell line was found to be defective in DNA double-strand break repair, but fails to express the p350 subunit of DNA-PK. These results suggest that DNA-PK kinase activity is involved in DNA double-strand break repair.
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