Biological therapies in breast cancer: Common toxicities and management strategies
Romualdo Barroso‐Sousa(Universidade de São Paulo), Iuri A. Santana(Instituto do Câncer do Estado de São Paulo), Laura Testa(Universidade de São Paulo), Débora De Melo Gagliato(Instituto do Câncer do Estado de São Paulo), Max S. Mano(Instituto do Câncer do Estado de São Paulo)
Cited by 30Open Access
Abstract
In recent years, a number of new molecules - commonly known as biological therapies - have been approved or are in late stages of regulatory evaluation for the treatment of advanced breast cancer. These innovative compounds have improved treatment efficacy and have probably contributed to the increase in survival length observed in some breast cancer subtypes. However, these agents are not deprived of toxicity, which can impair quality of life and may occasionally be life-threatening. In this article, we reviewed the most common toxicities associated with these drugs and provided a number of practical recommendations on their optimal clinical management.