Genetic analysis of vitamin D related genes in Canadian multiple sclerosis patients
J. L. Steckley(University of British Columbia), D. A. Dyment(University of British Columbia), A. Dessa Sadovnick(University of British Columbia), Neil Risch(University of British Columbia), Colleen E. Hayes(University of British Columbia), George C. Ebers(University of British Columbia), the Canadian Collaborative Study Group
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Abstract
The objective of this study was to investigate genes involved in the metabolism and function of vitamin D as candidate genes for genetic susceptibility to MS. Restriction fragment length polymorphisms and highly polymorphic microsatellite markers within or very close to the 1,25(OH)2D3 receptor (VDR) [12q14], the vitamin D binding protein (DBP) [4q12], and the 25(OH)D2 1alpha-hydroxylase [12q13] loci were analyzed for linkage or association with MS. We found no evidence for linkage or association of these candidate genes with MS in the Canadian population.
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