Enhancing Gene Targeting with Designed Zinc Finger Nucleases
Marina Bibikova(University of Utah), Kelly J. Beumer(University of Utah), Jonathan K. Trautman(University of Utah), Dana Carroll(University of Utah)
Cited by 814
Abstract
Gene targeting—the process of gene replacement by homologous recombination—is a very useful but typically inefficient technique ( [1][1] ). A general method for improving the efficiency of gene targeting would be valuable in many circumstances, as would the extension of this genetic tool to a
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