The Minimal Gene Complement of <i>Mycoplasma genitalium</i>
Claire M. Fraser(Philips (Finland)), Jeannine D. Gocayne(Philips (Finland)), Owen White(Philips (Finland)), Mark D. Adams(Philips (Finland)), Rebecca A. Clayton(Philips (Finland)), Robert Fleischmann(Philips (Finland)), Carol J. Bult(Philips (Finland)), Anthony R. Kerlavage(Philips (Finland)), Granger Sutton(Philips (Finland)), Jenny M. Kelley(Philips (Finland)), Janice L. Fritchman(Philips (Finland)), Janice F. Weidman(Philips (Finland)), Keith V. Small(Philips (Finland)), Mina Sandusky(Philips (Finland)), Joyce L. Fuhrmann(Philips (Finland)), David N. Nguyen(Philips (Finland)), Teresa R. Utterback(Philips (Finland)), Deborah M. Saudek(Philips (Finland)), Cheryl A. Phillips(Philips (Finland)), Joseph M. Merrick(Buffalo State University), Jean-François Tomb(Johns Hopkins University), Brian Dougherty(Johns Hopkins University), Kenneth F. Bott(University of North Carolina at Chapel Hill), Ping-Chuan Hu(University of North Carolina at Chapel Hill), T S Lucier(University of North Carolina at Chapel Hill), Scott N. Peterson(University of North Carolina at Chapel Hill), Hamilton O. Smith(Johns Hopkins University), Clyde A. Hutchison(University of North Carolina at Chapel Hill), J. Craig Venter(Philips (Finland))
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Abstract
The complete nucleotide sequence (580,070 base pairs) of the Mycoplasma genitalium genome, the smallest known genome of any free-living organism, has been determined by whole-genome random sequencing and assembly. A total of only 470 predicted coding regions were identified that include genes required for DNA replication, transcription and translation, DNA repair, cellular transport, and energy metabolism. Comparison of this genome to that of Haemophilus influenzae suggests that differences in genome content are reflected as profound differences in physiology and metabolic capacity between these two organisms.
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