Functional Brown Adipose Tissue in Healthy Adults
Kirsi A. Virtanen(Turku University Hospital), Martin E. Lidell(University of Gothenburg), Janne Orava(University of Turku), Mikael Heglind(University of Gothenburg), Rickard Westergren(University of Gothenburg), Tarja Niemi(Turku University Hospital), Markku Taittonen(Turku University Hospital), Jukka Laine(Turku University Hospital), N. Savisto(University of Turku), Sven Enerbäck(University of Gothenburg), Pirjo Nuutila(University of Turku)
Cited by 3,031Open Access
Abstract
Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy specimens of this tissue from the first three consecutive subjects and documented messenger RNA (mRNA) and protein levels of the brown-adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment, which showed numerous multilocular, intracellular lipid droplets, and with the results of biochemical analysis, these findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.
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