Multicolor Spectral Karyotyping of Human Chromosomes
Evelin Schröck(National Human Genome Research Institute), Stanislas du Manoir(National Human Genome Research Institute), Timothy Veldman(National Human Genome Research Institute), Brigitte Schoell(National Human Genome Research Institute), Johannes Wienberg(University of Cambridge), M.A. Ferguson‐Smith(University of Cambridge), Yi Ning(National Human Genome Research Institute), David H. Ledbetter(National Human Genome Research Institute), Irit Bar‐Am(Tel Aviv University), Dirk Soenksen(Applied Spectral Imaging (United States)), Yuval Garini(Applied Spectra (United States)), Thomas Ried(National Human Genome Research Institute)
Cited by 1,763
Abstract
The simultaneous and unequivocal discernment of all human chromosomes in different colors would be of significant clinical and biologic importance. Whole-genome scanning by spectral karyotyping allowed instantaneous visualization of defined emission spectra for each human chromosome after fluorescence in situ hybridization. By means of computer separation (classification) of spectra, spectrally overlapping chromosome-specific DNA probes could be resolved, and all human chromosomes were simultaneously identified.
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