Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Elizabeth H. Corder(Duke University), Ann M. Saunders(Duke Medical Center), Warren J. Strittmatter(Duke Medical Center), D. E. Schmechel(Durham VA Medical Center), P. C. Gaskell(Duke Medical Center), Gary W. Small(University of California, Los Angeles), Allen D. Roses(Duke Medical Center), J. L. Haines(Massachusetts General Hospital), Jeffery M. Vance(Duke Medical Center)
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Abstract
The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onset decreased from 84 to 68 years with increasing number of APOE-epsilon 4 alleles in 42 families with late onset AD. Thus APOE-epsilon 4 gene dose is a major risk factor for late onset AD and, in these families, homozygosity for APOE-epsilon 4 was virtually sufficient to cause AD by age 80.
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